#3976 THE ROLE OF GENDER DIFFERENCES AND MENOPAUSE IN OBESITY-RELATED RENAL DISEASE, RENAL INFLAMMATION AND LIPOTOXICITY

Abstract Background and Aims The pathogenesis of obesity related-renal disease is unknown. Gender differences may have a role in renal damage obesity. In particular, menopause can promote obese women. previous study we observed that male female mice developed albuminuria, hyperfiltration glomerulomegaly, these changes were more severe those ovariectomized females. this evaluated inflammation lipotoxicity model. Method Twenty-two males 57 females C57BL6/J randomized to standard diet (SD) or high fat (HFD) for six months. A group animals on SD o HFD was induce menopause. tissue cytokines: NF-κβ, IL-1β, MCP-1, TNF-α total lipid content, classes, fatty acid profile acids classes. Part the lipidomic analysis performed urine. Results Obese showed higher MCP-1 (Fig. 1). had IL-1β compared with not-ovariectomized 1B). lower pro-inflammatory (16:0, 16:1n-7 18:2n-6) anti-inflammatory (22:6 n-3) 2A). This pattern also specific classes Finally, exacerbated pattern, 18:0 phosphatidylcholine, DMA phosphatidylethanolamine low 16:0 triglycerides 2B-D). Conclusion conclusion, induces an unbalanced (pro-inflammatory) lipidic tissue. seems be enhanced after